The  DNA Database Department manages the COmbined DNA Index System (CODIS) which is  a nationwide database containing the DNA profiles of criminal offenders, 	crime  scene evidence, missing persons and their relatives. South Carolina Law  Enforcement Division (SLED) is the state repository for offender (both  		convicted offender and arrestee) DNA specimens required per S.C. Code Ann. §  23-3-620. 
			  Profiles  developed from these samples are for databasing purposes only.  A direct comparison cannot be performed  between profiles developed from these samples and evidence profiles.  If direct comparison is needed, a standard  with a proper chain of custody and collected using appropriate legal authority  should be obtained and submitted to the laboratory that will be performing the  DNA analysis on the evidence to which comparison is requested.
			  DNA  sample collection of qualifying offenders is a responsibility shared by  multiple agencies. Once collected, database samples must be submitted to SLED.  Upon receipt, the DNA samples are processed and analyzed. The results of these  analyses are entered into the CODIS database. The offender profiles are  searched against other profiles in the CODIS database with the intent to  provide investigative leads to unresolved cases.
			  In  the event of a hit, or match between crime scene evidence and a qualifying  offender sample, the results will be reported to the agency that submitted the  crime scene sample. This provides an investigative lead for the agency and,  depending on the probative value of the evidence, can provide probable cause  for an arrest. If an offender is arrested for a crime based on a CODIS hit,  another known standard must be collected from that individual with a documented  chain of custody for court purposes. This standard is then examined by the  crime laboratory that analyzed the crime scene evidence. The crime laboratory  will issue a DNA report including the results of the comparison and statistics.
			  Samples  from qualifying offenders are not considered evidence and are not treated as  evidence. SLED will retain qualifying offender samples indefinitely to aid both  future and past investigations. This also provides the ability to reanalyze  samples as new technologies are developed. 
			  CODIS  searches can also result in a forensic hit, where the DNA profile developed  from evidence in one case hits against the DNA profile developed from evidence  in another case. This provides an investigative lead that enables multiple  jurisdictions to coordinate their investigation efforts.    
			  DNA  technology can also be used as an aid to locate missing persons and identify  human remains. DNA profiles of unidentified persons are compared to DNA  profiles contained within the State DNA Database, including biological  relatives of missing persons. Unidentified person refers to the recovered  deceased (including body parts) or an individual who is unidentified  (individuals who can’t or refuse to identify themselves). 
			  For  Missing Persons cases, items used exclusively by the missing person (i.e.  toothbrush, razor) and known standards from biological relatives of the missing  person should be submitted for inclusion in CODIS.  First degree relatives are preferred  (parents, siblings, offspring), but further removed relatives are acceptable. A  consent form must be signed by each relative who submits a known standard. This  form is available from the DNA Database or DNA Casework Department. The  profiles from relatives of missing persons are only searched against  unidentified persons and are not searched against crime scene evidence.
			  STR,  Y-STR and mitochondrial DNA analysis will be performed as appropriate.  Standards collected from relatives of missing persons may be outsourced to a  CODIS participating laboratory for STR, Y-STR and/or mitochondrial DNA  analysis. 
			  Offender  DNA records are subject to expungement from the State DNA Database if  appropriate documentation is received from the Solicitor’s Office with  jurisdiction over the qualifying DNA offense and the offender meets the  eligibility requirements as described in S.C. Code Ann. § 23-3-660.