Enforcement begins January 1, 2011


The South Carolina Methamphetamine Precursor Electronic Monitoring System provides retailers and law enforcement with a comprehensive system that tracks all sales of ephedrine and related compounds and blocks sales that are over the legal amount.


The 2010 South Carolina Legislature passed Act 242 to control the sale and purchase of ephedrine and related compounds, used as precursors to manufacture methamphetamine.

  • Establishes legal limits for the sale and purchase of these products
  • Requires S.C. retailers who sell the products to electronically submit certain purchaser and transaction information to a statewide database
  • Provides retailers an exemption from participating in the NPLEx System if they only sell single dose packages of ephedrine based products or if they do not have a compatible point of sale system. Exempted retailers must continue to maintain written logs.  
  • Free of charge to all law enforcement and retailers in South Carolina
  • Notifies retailers at the time of purchase if the sale will exceed legal limits
  • Accessible to Law Enforcement for Investigative Purposes
  • http://www.nplexservice.com/

Appriss, the technology provider for NPLEx, offered on-site and online web-based training to pharmacies/retailers and law enforcement employees during the implementation roll-out of the system November 2010 through January 2011 at no cost. For pharmacies/retailers new to the NPLEx system, additional training is available from within the NPLEx application. Once the user logs in, they can go to the Help tab > Training to access training tutorial videos which are available at any time.

For users who prefer more interaction, Appriss does provide web-based webinar training sessions monthly. For a schedule of dates for either retailer or law enforcement training, please email learning@appriss.com.

During the implementation of NPLEx in the state of South Carolina late last year, South Carolina Licensed Pharmacies were provided account information in a separate letter from Appriss and do not need to request an NPLEx account. Please contact Appriss at SCNPLEx@appriss.com if you have not received the letter from Appriss.

If you are a newly registered pharmacy in the state of South Carolina, Appriss has established a process with the South Carolina Board of Pharmacy to obtain new store information each month. With this information, Appriss will setup and distribute NPLEx account information based on the file received from the Board of Pharmacy. South Carolina Licensed Pharmacies are not required to complete a survey for account access.

If you are a South Carolina Licensed Retailer who sells ephedrine, pseudoephedrine, and/or phenylpropanolamine based products, you are required to comply with South Carolina 2010 Act 242 that became effective on January 1st, 2011. Retailers who are required to comply with South Carolina 2010 Act 242 can request an NPLEx account through an online survey developed by Appriss, the technology provider for NPLEx. By completing the online survey, Appriss will receive the necessary information to set up an NPLEx account for your business. When completing the survey, you will need The NPLEx Project Code which is SCNPLEx and your Self-Certification Certificate Number issued by the DEA. If you do not know your DEA Self-Certification Certificate Number, please contact the NPLEx Customer Service Center by email at SCNPLEx@appriss.com.

Upon successful completion of the survey, Appriss will contact the retailer with an NPLEx account, and provide details regarding training opportunities, NPLEx support, point-of-sale (POS) integration, and other information related to reporting obligations. Retailers can begin using NPLEx once login information is received.

Click on the Link below to be directed to the survey.

NPLEx Survey

Please note, if you are a newly registered pharmacy in the State of South Carolina, Appriss has established a process with the South Carolina Board of Pharmacy to obtain new store information each month. With this information, Appriss will setup and distribute NPLEx account information based on the file received from the Board of Pharmacy.

South Carolina Licensed Pharmacies were provided account information in a separate letter from Appriss and do not need to request an NPLEx account. Please contact Appriss at SCNPLEx@appriss.com if you have not received the letter from Appriss.